FDA Issues New Enforcement Priorities for Unauthorized ENDS and Nicotine Pouch Products: What Manufacturers, Importers, and Retailers Should Know

FDA Vape Nicotine Pouch Enforcement Priority Guidance

FDA’s New Guidance Signals a More Targeted Enforcement Strategy for Vapes and Nicotine Pouches On May 8, 2026, the FDA issued final guidance titled “Enforcement Priorities for Certain New Tobacco Products Marketed Without Premarket Authorization.” The guidance applies to certain electronic nicotine delivery systems (ENDS) and oral nicotine pouch products that are currently marketed without…

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FDA General Wellness Guidance 2026: What Wearable and Digital Health Companies Can and Can’t Do Now

FDA 2026 General Wellness

If you’re building a wearable, wellness app, smart ring, recovery tracker, or connected health platform, FDA just updated the playbook — and the changes matter. On January 6, 2026, FDA issued a revised final guidance replacing its 2019 General Wellness policy. The update doesn’t rewrite the rules, but it meaningfully clarifies what companies using non-invasive…

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Will the FDA Eliminate Self-Affirmed GRAS? What the Proposed Rule Could Mean

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The conversation around self-affirmed GRAS is evolving quickly, with lawmakers and regulators signaling potential changes that could reshape how food ingredients are evaluated and brought to market. While the FDA has not eliminated the pathway, proposed reforms and increased scrutiny suggest that companies relying on this framework should begin preparing now. For businesses, the real…

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FDA GRAS Reform in 2026: What Food and Ingredient Companies Need to Know

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The landscape of food ingredient safety is entering a period of significant transition in 2026. For decades, the “Generally Recognized as Safe” (GRAS) pathway has allowed companies to bring new ingredients to market based on their own scientific determinations of safety. However, as the FDA implements a major restructuring of its Human Foods Program, the…

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The FDA’s Quality Management System Regulation (QMSR): What the New Inspection Framework Means for Medical Device Companies

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The medical device industry is currently navigating one of its most significant regulatory shifts in decades. For nearly thirty years, the Food and Drug Administration (FDA) relied on the Quality System Regulation (QSR) found in 21 CFR Part 820 to ensure the safety and efficacy of devices. However, the landscape has changed. To foster innovation…

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The FDA’s New Approach to “No Artificial Colors” Claims: Compliance Risks and Legal Considerations

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The U.S. Food and Drug Administration has announced a new enforcement approach to products labeled “no artificial colors,” signaling heightened scrutiny for food and beverage companies that rely on clean-label marketing. While the phrase may appear straightforward, the regulatory analysis behind it is far more nuanced. As outlined in the FDA’s official press announcement, the…

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503A vs 503B Compounding Pharmacies: Compliance Risks That Can Pull Products from the Market

Compounding Pharmacies

Compounding pharmacies play a critical role in patient care, especially when commercially available drugs cannot meet specific clinical needs. However, the regulatory distinction between traditional compounding and large-scale outsourcing remains one of the most common sources of enforcement exposure in the pharmaceutical space. Misunderstanding where that line is drawn can create compliance risks under 503a…

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Congress Targets the GRAS Process: Four Bills That Could Fundamentally Change FDA Food Ingredient Oversight

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GRAS Loophole For more than two decades, the FDA’s “generally recognized as safe” (GRAS) framework has allowed food ingredients to enter the U.S. market either through FDA notification or through a company’s internal “self-GRAS” determination without notifying the agency. That flexibility is now under renewed scrutiny. Four separate bills introduced in the 118th and 119th…

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